A Study Aiming to Demonstrate That the Addition of Intravenous (IV) Tranexamic Acid-Compared to Placebo-During Anterior Cruciate Ligament (ACL) Reconstruction Results in Reduced Blood Loss and Postoperative Pain

Various reconstruction and graft harvesting techniques are used for ACL reconstruction.The most common techniques involve harvesting one or more hamstring tendons. Thesetendons are harvested using minimally invasive approaches with "strippers," which do notallow for hemostasis at the base of the thigh‐specifically at the myotendinous junctionwhere the proximal end of the graft is severed. This lack of hemostasis consistentlyleads to varying degrees of bleeding in the hours or even days following surgery. Thisbleeding causes pain, hematomas, and muscle inhibition (particularly of the hamstrings),thereby hindering the resumption of activities and delaying physical therapy progress.Tranexamic acid is an antifibrinolytic agent currently gaining widespread use inorthopedic surgery to prevent intraoperative and postoperative bleeding, particularly inknee and hip arthroplasty. Numerous recent publications, including meta‐analyses, havedemonstrated its efficacy and safety. Only one study has investigated the effect oftranexamic acid in the context of ACL reconstruction, showing a reduction inpostoperative pain. The main objective is to evaluate the effect of intravenoustranexamic acid on hemoglobin loss at postoperative day 2 in patients undergoing primaryACL reconstruction with hamstring tendon harvesting on an outpatient basis.