Influence of histones on the antibody response in guinea pigs to vaccination with A-Aichi-2-68 (H3 N2) influenza virus.

Authors
Category Primary study
JournalInfection and immunity
Year 1973
The influence of total, F1, and F3 histones on the primary antibody response in guinea pigs to vaccination with influenza virus A/2/Aichi/2/68 (H3 N2) was investigated. It was found that histones can greatly reduce the immunoglobulin (Ig) M and, to a smaller degree, the IgG antibody response. The immunosuppressive effect of histones was found to depend critically on the dose of virus used for vaccination, on the type and dose of histones, and on the schedule of histone application.
Epistemonikos ID: f83ec9d75fa7315eaa6014ea56081d68d4cbf153
First added on: Sep 05, 2024