High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium.

Category Primary study
JournalEmerging infectious diseases
Year 2017
Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays.
Epistemonikos ID: f83105f11828125eb16ea18fd20551313572233b
First added on: Jan 05, 2023