Effect of nigella sativa in the treatment of chronic periodontitis

INTERVENTION: Control group:SRP with placebo Intervention 1: Intervention group:SRP with Mucoadhesive Locally Delivery Nigella Sativa extract 0.2%. Intervention 2: Intervention group:SRP with Mucoadhesive Locally Delivery Thymoquinone 0.02%. Intervention 3: Control group:SRP with placebo. Intervention group:SRP with Mucoadhesive Locally Delivery Nigella Sativa extract 0.2% Intervention group:SRP with Mucoadhesive Locally Delivery Thymoquinone 0.02% Placebo Treatment ‐ Drugs CONDITION: Chronic periodontitis Chronic periodontitis. ; Chronic periodontitis PRIMARY OUTCOME: Bleeding Index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Observed\Bleeding Index Muhlemann. Clinical attachment loss. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Williams Periodontal Probe. Gingival Index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Observed. Plaque index. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: plaque index Silness & Loe. Probing pocket depth. Timepoint: Baseline, one week, two weeks, one and three months after the intervention. Method of measurement: Williams Periodontal Probe. INCLUSION CRITERIA: INCLUSION CRITERIA: patient free from systemic illness; patient who had not taken periodontal therapy in the past 3 month Exlusion criteria: dissatisfaction and inability to comply with the follow‐up visit requirments; history of systemic illness; received antioxidants like vitamin C and E or ß‐Carotene; pregnant