The Hypertension Optimal Treatment in Children with Chronic Kidney Disease study

INTERVENTION: Description: 150 subjects for randomisation and n=150 age matched controls Blood pressure control, Control of clinic systolic blood pressure to target using ACEi therapy as first line agent. Followed up at 5 months CONDITION: Chronic kidney disease ; Urological and Genital Diseases ; Chronic kidney disease PRIMARY OUTCOME: The differences in LV mass between aggressive and standard treatment groups measured at 2 and 4 years SECONDARY OUTCOME: Differences in cIMT and PWV measured at 2 and 4 years INCLUSION CRITERIA: 1. Aged 2 to 15 years 2. Chronic kidney disease with eGFR between 15‐90 ml/min/1.73m2 for two consecutive measurements in the last 12 months 3. With or without anti‐hypertensive/s medications (irrespective of recent change/s in antihypertensive therapy) 4. Subjects with average clinic systolic BP <50th percentile and on no antihypertensive medication will be eligible as ?CONTROL? subjects only 5. Other ?CONTROL? subjects will include children with normal renal function and blood pressure attending hospital for unrelated medical review or siblings of subjects with CKD 6. Male and female participants