Efficacy and safety of a novel fish oil based lipid emulsion (SMOFlipid) compared with olive oil based lipid emulsion (Clinoleic) in term and near-term (>34 weeks) neonates – a randomised controlled trial

INTERVENTION: SMOFlipid intravenous lipid emulsion (soy oil, MCT(medium chain triglycerides), olive oil and fish oil based). Dose: 1g/kg on day 1 of study, 2g/kg on day2 and 3g/kg on day3 to day 7 of study CONDITION: Neonatal nutrition PRIMARY OUTCOME: Long Chain‐Poly Uunsaturated Fatty Acid (LC‐PUFA) levels in plasma and Red cell membrane analysis Plasma and Urinary F2‐isoprostane level by GC/MS (Gas chrmatography/Mass spectrometry) method SECONDARY OUTCOME: Phagocyte activation assay and cytokine production INCLUSION CRITERIA: 1) Term and near term neonates (>34 weeks) admitted in the neonatal unit at Princess Margaret Hospital and 2) Needing Parenteral Nutrition providing > 75% of energy expenditure requirements for at least 7 days