The efficacy of botulinum toxin A delivered via reservoir-backed microneedle patch for facial sebum reduction compared to normal saline: a randomized, split-face pilot clinical trial

INTERVENTION: 20 unit(1ml) of botulinum toxin A delivered via resorvoir‐ backed microneele patch at one side of narsal dorsum and cheek, applied for 15 minutes,1 ml of normal saline delivered via resorvoir‐ backed microneele patch at one side of narsal dorsum and cheek, applied for 15 minutes Botulinum toxin A delivered via resorvoir‐backed microneedle patch,Normal saline delivered via resorvoir‐backed microneedle patch Experimental Drug,Placebo Comparator No treatment CONDITION: Healthy Thai adult aged 18 to 40 years with oily facial skin ; Oily skin, Seborrhea, botulinum toxin A, resorvoir‐backed microneedle patch, microneedle patch Oily skin, Seborrhea, botulinum toxin A, resorvoir‐backed microneedle patch, microneedle patch PRIMARY OUTCOME: Sebum level At 1 month and 4 months after end of the intervention Sebumeter SECONDARY OUTCOME: Feature count of pore At 1 month and 4 months after end of the intervention VISIA 7th generation,Quality of life At 1 month and 4 months after end of the intervention Oily skin self‐image questionnaire ,Patient satisfaction At 1 month and 4 months after end of the intervention Likert satisfaction scale,Adverse event At postintervention, 48 hours, 1 month and 4 months after end of the intervention Visual analogue scale INCLUSION CRITERIA: 1. Healthy Thai adult aged 18‐40 years 2. Clinical oily facial skin with 15 or more of Six‐item skin oiliness scale score 3. Elevated baseline ebum level at nasal dorsum and cheek morethan 106 microgram per square centimeters 4. Willing to refrain from using othe sebum reduction treatment during study period 5. Provided informed consent form