Dexamethasone effect on oral glucose tolerance test

INTERVENTION: A single oral 8 mg dexamethasone tablet one time first day A single oral 8 mg placebo tablet one time First day Intervention 1: A single oral 8 mg placebo tablet one time First day. Intervention 2: A single oral 8 mg dexamethasone tablet one time first day. Placebo CONDITION: Diabetes mellitus diabetes mellitus. ; Diabetes mellitus E10‐E14 PRIMARY OUTCOME: Plasma glucose in 0,30,60,120 minutes durig OGTT. Timepoint: first day and second day. Method of measurement: mmol/l. Plasma insulin in 0,30,60,120 minutes during OGTT. Timepoint: first day and second day. Method of measurement: pmol/l. SECONDARY OUTCOME: AUC(g)=Area under the curve of glucose. Timepoint: first day and second day. Method of measurement: By related formulae. AUC(i) / AUC(g). Timepoint: first day and second day. Method of measurement: By related formulae. AUC(i)= Area under the curve of insulin. Timepoint: first day and second day. Method of measurement: By related formulae. Disposition index. Timepoint: first day and second day. Method of measurement: By related formulae. Homa‐B index. Timepoint: first day and second day. Method of measurement: By related formulae. HOMA‐IR index. Timepoint: first day and second day. Method of measurement: By related formula. Insulinogenic index. Timepoint: first day and second day. Method of measurement: By related formulae. Matsuda index. Timepoint: first day and second day. Method of measurement: By related formulae. INCLUSION CRITERIA: INCLUSION CRITERIA:20‐65 years old individuals with first degree relative of diabetic patients Exclusion criteria: Active peptic ulcer? active herpetic corneal ulcer? psychosis? positive pregnancy test? current use of oral contraceptives in women and thiazide or glucocorticoids use in any person