Therapeutic effect of curcumin in symptoms of mild to moderate Alzheimer's disease

Inclusion criteria: Inclusion Criteria : Sign informed consent ; mild Alzheimer; with out any of psychic disorder Exclusion Criteria : Discontinue of treatment more than 2 weeks ; disese becomes out of control ; allergic reaction to herbal compounds ,abnormal results in lab tests Exclusion criteria: Intervention 1: intervention group: curcumin capsule, twice a day for 12 weeks . Intervention 2: control group:placebo of curcumin, twice a day for 12 weeeks . Improvment of mental state. Timepoint: before and after of intervention (12 weeks). Method of measurement: MMSE questionaire;Improvment of quality of life. Timepoint: before and after of intervention (12 weeks). Method of measurement: quality of life questionnaire Interleukin18 (IL18). Timepoint: befor and after of intervention(12 weeks). Method of measurement: level of serum;superoxide dismutase (SOD). Timepoint: before and after of intervention(12 weeks). Method of measurement: level of serum;Glutathione peroxidase (GPO). Timepoint: before and after of intervention(12 weeks). Method of measurement: level of serum;malondialdehyde(MDA). Timepoint: befor and after of intervention(12 weeks). Method of measurement: level of serum