Effects of using Colchicine for the prevention of inflammatory complications, arrhythmias and pain control in the postoperative period of cardiac surgery.

INTERVENTION: D03.132.225 Total 60 patients were recruited for the study. The randomization of the sample was performed to allocate the subjects in the group submitted to the use of placebo (placebo group) and in the group submitted to therapy with colchicine (colchicine group). Medication dose of 0.5 mg twice daily in patients over 70 kg and once daily in patients below 70 kg. Placebo or colchicine were administered from the day of preoperative hospital admission (one day before surgery), restarted postoperatively as soon as patients could receive food, and continued until 30 days after cardiac surgery. CONDITION: Atrial Fibrillation; Pain; Pleural Effusion; Pericarditis; Other functional disturbances following cardiac surgery. PRIMARY OUTCOME: Colchicine did not alter the occurrence of post‐pericardiotomy syndrome and had a small effect size (greater than 0.02) on pain control, assessed using the Visual Analog Pain Scale (VAS), which is an instrument self‐report, consisting of colors and facial expressions in which the degree of pain varies from zero to ten, with zero meaning total absence of pain and ten, the level of maximum bearable pain. SECONDARY OUTCOME: 51% improvement in C‐reactive protein indices in patients who used Colchicine in the postoperative period of cardiac surgery, evaluated through blood sample considering reference value less than 0.6 mg/dL for the presence of inflammation considering the present values in the post‐intervention and in the immediate postoperative period. INCLUSION CRITERIA: Patients in post operative of cardiac surgery; both sexes; age 18 to 85 years.