The effects of the combination of glucosyl-hesperidin and caffeine on serum triglyceride and visceral fat in human dose-finding study: double-blind, placebo-controlled trial

INTERVENTION: Oral ingestion of the control food (placebo,1 g/day,tablets) for 12 weeks Oral ingestion of the test food 1 (containing 470 mg glucosyl hesperidin,1 g/day,tablets) for 12 weeks Oral ingestion of the test food 2 (containing 470 mg glucosyl hesperidin and 25 mg caffeine,1 g/day,tablets) for 12 weeks Oral ingestion of the test food 3 (containing 470 mg glucosyl hesperidin and 50 mg caffeine, 1 g/day,tablets) for 12 weeks Oral ingestion of the test food 4 (containing 470 mg glucosyl hesperidin and 75 mg caffeine, 1 g/day,tablets) for 12 weeks CONDITION: moderately high body mass index (24‐30 kg/m2) with 100‐250 mg/dL serum triglycerid, healthy subjects PRIMARY OUTCOME: Abdominal fat area (subcutaneous fat area and visceral fat area) at 0 and 12‐week ingestion period SECONDARY OUTCOME: At 0, 4, 8 and 12‐week ingestion period ; [1]serum triglyceride; [2]body weight; [3]body mass index (BMI) INCLUSION CRITERIA: [1]20‐65 years old male and female [2]serum triglyceride:100‐250 mg/dL [3]body mass index(BMI):24‐30 kg/m2