Randomized controlled trial to evaluate the effect of neurologic modulation associated with conventional pain treatment versus conventional pain treatment in cancer patients with moderate to severe pain

INTERVENTION: C23.888.592.612.212 Cellular neuromodulation therapy electromagnetic equipment (REAC technology), an application is made by a tissue nanoconductor in the shoulder and neck region or in the ear. 18‐cycle therapy three times a week, administration with protocols NPO (neuro postural optimization), NPPO (neuromodulation neuropsychophysic) ou ANM (antalgic neuro modulation) specific to each arm patients with oncologic moderate to severe pain , in use of weak or strong opioids 120 patients in total . each arm will have 40 patients CONDITION: C00‐D48 cronic pain intractable. malignant neoplasm localization unspecified R00‐R99 PRIMARY OUTCOME: Assess at least one level reduction in the depression, anxiety scale and stress 21 in the neuromodulation intervention arm; ; To assess pain perception change with at least 30% reduction in scale; Analog Visual Pain in the neuromodulation intervention arm; SECONDARY OUTCOME: Evaluate serum level of interleukins and its relation with the evolution of treatment in all subgroups ; Evaluate the reduction in the amount of rescue medication used by the patient during the study in the neuromodulation intervention arm; ; Evaluate the tolerability and safety of neuromodulation associated with analgesia classical; Improvement of quality of life measured by the Eastern Cooperative Oncology group questionnaire in the neuromodulation intervention arm; To evaluate the improvement of the degree of pain in the subgroup of patients with neuropathy in the neuromodulation intervention arm; INCLUSION CRITERIA: patients with malignant neoplasia with moderate to severe pain; use of World Health OrganizationlLadder level 2 or 3 analgesics; cause of pain should be primarily cancer or its treatment; Age upper 18 years; Eastern Cooperative Oncology group performance status minus than 3; proper cognitive function to correctly complete the questionnaires; Availability for blood sample collection for evaluation of inflammatory parameters