Green tea supplementation and dental care for neurological outcome in patients undergoing major abdominal surgery

INTERVENTION: Intervention1: Oral care group: Twice daily brushing for 2 minutes starting 5 days preoperatively Intervention2: Green tea group: Twice daily green tea intake 5 days preoperatively Intervention3: Combined oral care and green tea group: Both twice daily brushing for 2 minutes and twice daily green tea intake 5 days preoperatively Control Intervention1: Control roup: Control arm (once daily brushing and no green tea) CONDITION: Health Condition 1: K801‐ Calculus of gallbladder with othercholecystitis Health Condition 2: K311‐ Adult hypertrophic pyloric stenosis Health Condition 3: K742‐ Hepatic fibrosis with hepatic sclerosis PRIMARY OUTCOME: Incidence ofpostoperative deliriumTimepoint: first 48 hours after surgery SECONDARY OUTCOME: Quality of recoveryTimepoint: at 24 hours To compare CRP and procalcitoninTimepoint: baseline, 3rd and 5th postoperative days To compare oral microbiological floraTimepoint: at baseline and after 5 postoperative days To compare severity of postoperative deliriumTimepoint: first 48 hours after surgery To determine bowel recovery following surgeryTimepoint: To determine possible adverse effects (e.g., caffeine‐related effects, gastrointestinal irritation, mouthwash sensitivities)Timepoint: first 48 hours after surgery To evaluate duration of mechanical ventilationTimepoint: first 48 hours after surgery To evaluate the ICU & hospital length of stayTimepoint: To explore postoperative respiratory adverse eventsTimepoint: first 48 hours after surgery INCLUSION CRITERIA: Patient of ASA grade I‐III, elective major abdominal surgery (intra‐peritoneal operation with no primary involvement of the thora Xinvolving either luminal resection and/or resection of solid organ associated with gastro intestinal tract for duration at least 2 hours, Planned for general anesthesia with or without regional anesthesia and expected postoperative stay more than 5 days