Synergistic comparison of the effectiveness of cognitive-behavioral therapy and cranial direct current stimulation therapy on the dorsal lateral prefrontal cortex on reducing cravings and clinical signs and improving neuropsychological functions in Stimulant substance abusers

Authors
Category Primary study
Registry of TrialsIranian Registry of Clinical Trials
Year 2023
INTERVENTION: Intervention 1: Intervention group: treatment only (CBT) In order to investigate the effectiveness of cognitive behavioral therapy on the dependent variables of the research (reduction of basic and induced cravings, reduction of clinical symptoms of anxiety and depression, and improvement of neuropsychological functions i.e. cognitive inhibition and behavioral inhibition) in the treatment of patients with (amphetamine) abuse disorder ) The people receiving this intervention, who are 10 people, will only undergo cognitive behavioral therapy according to the designed protocol (10 sessions of 45 minutes). Intervention 2: Intervention group: Treatment only (tDCS) Intervention group: only treatment (tDCS) in order to investigate the effectiveness of stimulation treatment with direct current from the skull on dependent variables (reduction of basic and induced cravings, reduction of clinical symptoms of anxiety and depression, and improvement of neuropsychological functions, i.e. cognitive inhibition and behavioral inhibition) In the treatment of patients suffering from (amphetamine) abuse disorder, the people receiving this intervention, who are 10 people, will only be treated with direct current stimulation from the skull with the right anode‐left cathode protocol (10 sessions) of 20 minutes. Intervention 3: Intervention group: therapy (CBT) and therapy (tDCS) Intervention group: treatment (CBT) and treatment (tDCS) in order to investigate the effectiveness of co‐administration (combination) of cognitive behavioral therapy with stimulation therapy with direct current from the skull on the d CONDITION: addiction. ; Mental and behavioural disorders due to use of other stimulants, including caffeine F15.1 INCLUSION CRITERIA: Primary diagnosis of amphetamine abuse based on clinical interview based on DSM‐5 Age range 20‐50 years He had at least middle school education Lack of diagnosis of any psychiatric disorder (except substance abuse) Not receiving any psychiatric medication for at least 6 months before entering the study Not receiving any other psychological intervention during the study Subjects' consent to participate in the research Not suffering from any specific physical disease Not suffering from neurological diseases (epilepsy, multiple sclerosis). PRIMARY OUTCOME: Clinical symptoms (anxiety and depression). Timepoint: Before the intervention, a pre‐test will be done from all four groups (three experimental groups and one control group) by implementing research questionnaires. Then, test group 1 received cognitive‐behavioral therapy (CBT) and test group 2 received tDCS (DLPFC area) with the right anode‐left cathode protocol and the third group received both treatments to check synergy. will do And the control group will not receive any intervention.After the implementation of the intervention, a post‐test of all four groups will be conducted by implementing research questionnaires. Method of measurement: questionnaire Beck depression questionnaire Beck's anxiety. Craving for basic and induced amphetamines. Timepoint: Before the intervention, a pre‐test will be done from all four groups (three experimental groups and one control group) by implementing research questionnaires. Then, test group 1 received cognitive‐behavioral therapy (CBT) and test group 2 received tDCS (DLPFC area) with the right anode‐left cathode protocol and the third group received both treatments to check synergy. will do And the control group will not receive any intervention.After the implementation of the intervention, a post‐test of all four groups will be conducted by implementing research questionnaires. Method of measurement: Questionnaire Amphetamine baseline craving questionnaire Video test to measure induced craving. Functions of neuropsychology (cognitive and behavioral inhibition). Timepoint: Before the intervention, a pre‐test will be done from all four groups (three experimental groups and one control group) by implementing research questionnaires. Then, test group 1 received cognitive‐behavioral therapy (CBT) and test group 2 received tDCS (DLPFC area) with the right anode‐left cathode protocol and the third group received both treatments to check synergy. will do And the control group will not receive any intervention.After the implementation of the intervention, a post‐test of all four groups will be conducted by implementing research questionnaires. Method of measurement: Neuropsychological Test of Behavioral Inhibition GO‐NO GO‐NO‐GO (1984) Stroop cognitive inhibition neuropsychology test (1935).
Epistemonikos ID: f40acf3588dadaeab1508a2a2a0fdd823efd5730
First added on: Feb 20, 2024