Different Ozone Concentrations for Knee Osteoarthritis

Background: Knee osteoarthritis (KOA) is a prevalent joint disorder globally, resultingin pain and disability, with various treatment options available. Intra‐articular ozone(O2‐O3) administrations are an efficient therapeutic approach commonly employed in thiscondition. With this study, we aimed to compare the effect of varying ozoneconcentrations on treatment outcomes.Method: This multicenter single‐blind, cohort study was conducted at two distinctuniversity hospitals between May 2023 and September 2024. Patients who underwentintra‐articular knee ozone injection were examined and divided into two groups as 15μg/ml (Group A) and 25 μg/ml ozone (Group B). Participants' pain scores were measured byNumeric Rating Scale (NRS), functional status by Western Ontario and McMasterUniversities Arthritis Index (WOMAC) and quality of life by Short Form‐12 (SF‐12) beforeand at 1 and 3 months following ozone therapy.