Lifestyle Modification Programme for HIV-infected Individuals With Fatty Liver

Non‐alcoholic fatty liver disease (NAFLD) is rising in prevalence, and will likely become the predominant cause of chronic liver disease in HIV‐infected individuals. Metabolic factors and obesity are important risk factors for NAFLD in HIV‐infected individuals. There is currently no approved effective pharmacological treatment for fatty liver disease. Therefore, lifestyle modification directing at weight loss is currently the cornerstone of treatment for fatty liver disease in the general population. Hypocaloric diets can improve fatty liver in the general population, but the most effective specific dietary interventions are yet to be elucidated. The study aims to 1. determine the efficacy of a lifestyle modification programme in inducing resolution of NAFLD in HIV‐infected individuals 2. to determine the efficacy of a lifestyle modification programme in improving insulin resistance, pro‐inflammatory markers, and liver fibrosis in HIV‐infected individuals with fatty liver disease 3. to determine changes in intestinal microbiome secondary to the lifestyle modification programme, and the association with resolution of NAFLD in this group of patients.