Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo.

Category Primary study
JournalJournal of the National Cancer Institute
Year 1980
5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTTP levels in rapidly frozen 12-day W rat embryos and in a human neuroblastoma grown in nude N:NIH(S) mice to about 20% of control values. This effect was associated with greatly increased dCTP levels and reduction of dGTP levels essentially to zero. Elimination of the dGTP pool correlated temporally with the cytotoxicity of FdUrd. Extremely rapid fixation of tissue was required to avoid artifactually high deoxyribonucleoside triphosphate values.
Epistemonikos ID: f24f4e845c63ef746f5738fac0e0c7cd13a0dfe5
First added on: Apr 13, 2022