Effect of Sulfasalazine On Seminal Parameters

INTERVENTION: Intervention1: Sulfasalazine tablets: sulfasalazine tablets 1g will be given twice daily will be given orally for 3 months Control Intervention1: methotrexate: methotrexate 10 mg tablets will be given orally once weekly for 3 months Control Intervention2: etanercept injection: etanercept 50 mg once weekly will be given subctaneously for 3 months Control Intervention3: Infliximab: infliximab as intravenous infusion for 3 months. Dose of 5 mg/kg given as an intravenous induction regimen at 0, 2 and 6 weeks followed by a maintenance regimen of 5 mg/kg every 8 weeks thereafter CONDITION: Health Condition 1: M059‐ Rheumatoid arthritis with rheumatoid factor, unspecified Health Condition 2: M498‐ Spondylopathy in diseases classified elsewhere Health Condition 3: K519‐ Ulcerative colitis, unspecified Health Condition 4: M469‐ Unspecified inflammatory spondylopathy PRIMARY OUTCOME: 1. Change in seminal parameters from the baseline at the end of the study i.e. 3 months in patients with spondyloarthritis , rheumatoid arthritis, ulcerative colitis. ; 2. Adverse reactions reported in patients with spondyloarthritis , rheumatoid arthritis, ulcerative colitis ; Timepoint: at baseline and at 90 days SECONDARY OUTCOME: Change in complete blood count parameters from baseline to the end of study in patients with spondyloarthritis , rheumatoid arthritis, ulcerative colitis .Timepoint: baseline and at 3 months INCLUSION CRITERIA: 1. Male patient aged 18‐60 years diagnosed with in male patients with spondyloarthritis , rheumatoid arthritis, ulcerative colitis. 2. Patient giving written informed consent and willing to comply with study related procedures