Use of megadoses of vitamin C in the healing and disinflammation of surgical wounds

Background: There is still controversy over how to recommend the use of high doses of Vitamin C in treatment of patients in hospitals. Objective: To determine the clinical usefulness of Vitamin C at high doses intravenously. Methodology: Review of academic articles available in MedLine, EMBASE, Cochrane, ScienceDirect, Scopus, Scielo, Pubmed, Medigraphic, Elsevier and Virtual Health. Results: The use of megadoses of vitamin C afer asurgical procedure has favorable effects in the resolution of the inflammatory process at doses of 3 grams per day administered parenterally. Sometimes it is used as a coadjuvant in the wound healing process at doses of 4 grams per day with beneficial effects and against wound dehiscence. These properties are explained by the ability of ascorbic acid to decrease the activity of proinflammatory cytokines, and in addition to its participation in the synthesis of collagen type I, indispensable element for an adequate scar formation. Conclusions: Several studies have shown the benefits of using megadoses of vitamin C after a surgical procedure.