Comparative Efficacy of Preoperative Analgesics on The Success of Inferior Alveolar Nerve Block in Mandibular Molars with Acute Irreversible Pulpitis: a Randomized Controlled Clinical Trial

INTERVENTION: Diclofenac potassium Placebo Trypsin Chymotrypsin Alphintern Trypsin Chymotrypsin Ambezim G CONDITION: ; Oral Health ; Anaesthesia Anaesthesia Oral Health PRIMARY OUTCOME: Success of inferior alveolar nerve block anesthesia, defined as the ability to complete access cavity preparation and initial pulp extirpation with no or mild pain without the need for supplemental anesthesia SECONDARY OUTCOME: Electric pulp test EPT response Pain intensity measured using the Visual Analog Scale (VAS) INCLUSION CRITERIA: * Patients aged 18–50 years. * Healthy individuals classified as ASA I or II. * Mandibular first or second molars diagnosed with acute irreversible pulpitis. * Moderate to severe spontaneous pain. * Positive response to electric pulp testing. * Prolonged response to cold testing. * Absence of periapical radiolucency. * Closed root apices. * Ability to understand the visual analogue scale.