Study of Whole-brain Irradiation With Chloroquine for Brain Metastases

Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2011
Background and purposes:Chloroquine (CLQ), an antimalarial drug, has a lysosomatrophic effect associate with increase the sensibility of Radiation through leakage of hidroliticenzimes, increase of apoptosis, autophagy mediated by lysosomalhidrolases and increase of oxidative stress \"in vitro\". In this phase II study we evaluated the efficacy and safety as radiosensitizing of the Chloroquine plus concomitant 30 Gray (Gy) of Whole-brain irradiation (WBI)in patients with brain metastases (BM) from solid tumors.
Epistemonikos ID: f0ea9131691285c5344804464ad4c78251a08e50
First added on: May 11, 2024