Comparison of cinnarizine and sodium valporate in migraine prophylaxis

INTERVENTION: Cinnarizne tablet 25 mg twice a day orally, for 12 weeks Intervention 1: Cinnarizne tablet 25 mg twice a day orally, for 12 weeks. Intervention 2: Sodium valporate tablets 200mg twice a day orally, for 12 weeks. Sodium valporate tablets 200mg twice a day orally, for 12 weeks Treatment ‐ Drugs CONDITION: Condition 1: Common migraine. Condition 2: Classical migraine. ; Migraine without aura [common migraine] ; Migraine with aura [classical migraine] Migraine with aura [classical migraine] Migraine without aura [common migraine] PRIMARY OUTCOME: Analgesic use. Timepoint: every 4 week. Method of measurement: According to patients daily notes. Duration of migraine attack. Timepoint: in each migraine attack. Method of measurement: patient records the hours of headache in each attack , physician register them every 4 weeks. Headache frequency. Timepoint: every 4 week. Method of measurement: According to patients daily notes. Severity of headache. Timepoint: in each migraine attack. Method of measurement: patient will record the headache severity in daily notes as VAS (from 1 to 10) & physician registers them every 4 weeks. SECONDARY OUTCOME: Clinical side effects. Timepoint: every 4 weeks. Method of measurement: According to patients daily notes. INCLUSION CRITERIA: INCLUSION CRITERIA: more than 4 and less than 10 attacks monthly, age at the onset of headache less than 50 years, age 18‐65 years, discontinuation of other prophylactic drugs one month prior to the study, interval between attacks more than 48 hours Exclusion criteria: pregnancy and breast feeding, non‐migraine headaches, overuse of medications in migraine attacks (consumption of NSAID, Ergots & Triptans more than 8 days a month), substance and alcohol abuse, illiteracy of patients and their family (unable to fill diaries)