武汉市 55 例新型冠状病毒肺炎病例临床特征分析及疗效评价* / Clinical characteristics of 55 hospitalized patients with COVID-19 in Wuhan, China.

OBJECTIVE: To analyze the clinical characteristics and efficacy of patients with COVID-19 in Huangpi District，Wuhan. METHODS: 55 patients’ medical history data were collected, blood routine examination，hepatic function and other tests were conducted the following day after hospitalization，and comprehensive treatment plans were taken according to patient’s condition and the condition changes were recorded. RESULTS: The average age of COVID-19 patients was 53. 9±17. 1 years old. There were 45 mild patients (81. 8%), 9 severe patients(16. 4%) and 1 serious patients (1. 8%). The ratio of male to female was 1. 3:1. Fever(70. 9%)and cough(56. 4%)were the main clinical manifestations. Other symptoms included expectoration(36. 4%)，anhe- lation(27. 3%)，dyspnea(5. 5%)，diarrhea(1. 8%)，asymptomatic(1. 8%). In the blood biochemical exami- nation，the numeration of leukocyte was mostly normal or decreased(98. 2%)，the lymphocyte count was de- creased in most patients(58. 2%)，and the ALT and/or AST increased in some patients(27. 3%). Compared with the mild patients，the mean age of the severe patients was higher(P=0. 008)and the lymphocyte count was significantly lower(P=0. 008). The effective rate was 95. 6% for mild patients and 90. 0% for severe pa- tients. CONCLUSION: Elderly and low lymphocyte count may be risk factors for COVID-19 patients progress tosevere state in Huangpi District，Wuhan. In addition to symptomatic and supportive treatment，the combi- nation of antiviral，Chinese patent medicine and hor- mone is fair for severe patients. Keywords novel coronavirus ;pneumonia ;COVID- 19;clinical features;efficacy evaluation