Baclofen for Alcohol Dependence

INTERVENTION: 12‐week intervention comparing oral baclofen 10mg t.i.d versus oral baclofen 20mg t.i.d. for the treatment of alcohol dependence, and incorporating a manualised behavioural therapy for all participants. CONDITION: Alcohol Dependence PRIMARY OUTCOME: Number and severity of side‐effects reported across the 12‐week treatment period Reduction in self‐reported anxiety and craving Reduction in the proportion of heavy drinking days across the 12‐week treatment period compared to baseline drinking SECONDARY OUTCOME: Changes in liver function biomarkers (AST, ALT, GGT, bilirubin). INCLUSION CRITERIA: DMS‐IV criteria for alcohol dependence; Meets criteria for current heavy drinking; Can provide informed written consent; 3‐days abstinence prior to treatment; Desires abstinence or to greatly reduce alcohol consumption; Has stable residence and can provide collateral contact details.