A Clinical Trial To Study The Effect Of Three Drug On Post Operative Pain With Ropivacaine And Dexamethasone Vs Ropivacaine with Dexmedetomidine In Patient Undergoing Laproscopic Cholecystectomy

INTERVENTION: Intervention1: Ropivacaine with dexamethasone: Ropivacaine for inraperitoneal instillation as it provides prolonged analgesia has lower cardiotoxicity and neurotoxicity compared to bupivacaine, making it safer, especially in higher volumes. It offers greater sensory than motor block, which allows effective pain relief without impairing motor functionthis promotes early ambulation and recovery Hence we used ropivacaine 0.375 % 30ml . Also adjuvants like Dexamethasone a potent corticosteroid has anti‐inflammatory and antiemetic properties. It prolongs the duration of analgesia when used as an adjuvant by reducing nociceptive mediators and inflammation at the surgical site .In our strudy we used Dose‐ 8mg dexamethasone Control Intervention1: Ropivacaine with dexmedetomidine: Dexmedetomidine a selective alpha 2 adrenergic agonist provides analgesic anxiolytic and mild sedative effects without causing respiratory depression It acts synergistically with local anesthetics to enhance analgesia through both peripheral and central mechanisms Control Intervention2: Ropivacaine with Dexamethasone: adjuvants like Dexamethasone along with with Ropivacaine Dexamethasone is a potent corticosteroid, has anti‐inflammatory and antiemetic properties It prolongs the duration of analgesia when used as an adjuvant by reducing nociceptive mediators and inflammation at the surgical site In our strudy we used Dose‐ 8mg dexamethasone CONDITION: Health Condition 1: O‐ Medical and Surgical PRIMARY OUTCOME: Compare the efficacy of intraperitoneal instillation of Ropivacaine with Dexamethasone versus Ropivacaine with dexmedetomidine for postoperative analgesia after Laparoscopic cholecystectomyTimepoint: AFTER 30 MIN 1 HRS 2 HRS 4 HRS 6 HRS 12 HRS 24 HRS SECONDARY OUTCOME: NILTimepoint: NIL INCLUSION CRITERIA: Age between 18 and 65 years, either se X American Society of Anesthesiologists (ASA) physical status I or II. Scheduled for elective laparoscopic cholecystectomy under general anesthesia. Able to understand the study protocol and willing to provide written informed consent.