Glucose homeostasis and insulin secretion during chronic treatment with cyclosporin in nondiabetic humans

Cyclosporin or placebo was administered in a randomized, double‐blind fashion to 13 patients with multiple sclerosis for 1 yr to determine whether cyclosporin adversely affects glucose homeostasis or beta‐cell function. No significant differences were observed in fasting glucose, fasting insulin, intravenous glucose tolerance, or glucose‐induced insulin secretion before treatment or at 3 wk, 6 mo, or 1 yr during treatment. Longer therapeutic trials with larger patient groups will be necessary to decide whether cyclosporin can be safely given for many years without risk of developing diabetes mellitus.