Synthesis and biological activity of lactones en route to Altohyrtin A.

Authors
Category Primary study
JournalBioorganic & medicinal chemistry letters
Year 1998
Lactones 2 and 7 were synthesised and tested against six human tumour cell lines (Pancreas-a, BXPC-3), (Thyroid ca, KAT-4), (Thyroid ca, SW1736), (Lung-NSC, NCI-H460), (Pharynx-sq, FADU) and (Prostate, DU-145). Lactone 7 proved inactive, but lactone 2 displayed some activity against four of the six cell lines examined. Both lactones were converted into an intermediate 5 en route to Altohyrtin A.
Epistemonikos ID: eda5ab0113504da55aebce8d928aa0a43e973d99
First added on: Apr 14, 2022