The effects of alpha-lipoic acid supplementation on muscle atrophy after anterior cruciate ligament reconstruction.

INTERVENTION: Intervention1:alpha‐lipoic acid, Dose form:CAPSULE, Route of administration:ORAL, intended dose regimen:Subjects were randomly assigned to one of two oral‐supplementation treatment groups. Supplements, taken twice daily, contained either alpha‐lipoic acid (105 mg) or placebo. . Control intervention1:Placebo, Dose form:CAPSULE, Route of administration:ORAL, Intended dose regimen:Subjects were randomly assigned to one of two oral‐supplementation treatment groups. Supplements, taken twice daily, contained either alpha‐lipoic acid (105 mg) or placebo. . CONDITION: anterior cruciate ligament reconstruction PRIMARY OUTCOME: muscle volume. Timepoint:baseline, post 1 month. SECONDARY OUTCOME: oxidative stress markers, inflammation markers. Timepoint: baseline, pre, immediately after, post 90 min, post 3 day, post 7day, post 1 month. INCLUSION CRITERIA: The patients diagnosed as anterior cruciate ligament injury.