Effect of Insulin Glulisine vs Regular Human Insulin on Postprandial Endothelial Function in Type 2 Diabetes

The primary objective of the study is to evaluate the postprandial time course of nitrotyrosine after injection of insulin glulisine compared with regular human insulin. The secondary objectives are to evaluate the postprandial time course of the following efficacy parameters after injection of insulin glulisine compared with regular insulin on * Blood Glucose * Insulin * Intact proinsulin * Asymmetric dimethylarginine (ADMA) * Metal matrix proteasis (MMP-9) * Oxidative status (per ox) * Interleukin 18 (IL-18) * Free fatty acids (FFA) * Oxidised LDL (ox-LDL) * Microvascular blood circulation measured with laser Doppler at 37 °C (LDF37) * Microvascular blood circulation measured with laser Doppler at 44 °C (LDF44)