Subgroup analysis of hypotensive effects of lactic acid bacteria beverage containing chicken collagen hydrolysate in subjects with high-normal blood pressure

Objectives: Chicken collagen hydrolysate (Chicken-Collagen Octa Peptides; C-COP) contains a peptide with angiotensin converting enzyme (ACE)-inhibitory activity. 12 weeks of C-COP administration at 2.9 g/day has already been found to reduce blood pressure in humans. Here, we sub-analyzed the efficacy of C-COP to the subjects with high-normal blood pressure. Methods: Blood pressure were analyzed during 2 observational weeks before treatment of 120 subjects with mild hypertension. 80 subjects who recorded below the high-normal blood pressure in this period were chosen as the study subjects with high-normal blood pressure. These subjects were randomly grouped into a test-food group (41) which was given a lactic acid bacteria drink containing C-COP at 2.9 g/day, and a placebo control group (39). The clinical trial designed a double-blind, placebo-controlled to investigate the hypotensive action of C-COP. Results: In the test-food group, systolic blood pressure was significantly reduced compared with the placebo group at 8 and 12 weeks after the intake of the test-food (p<0.05). When compared with the baseline values, a reduction in blood pressure was found at 2, 10 and 12 weeks in the test-food group (p<0.01, p<0.1 and p<0.1, respectively). Furthermore, a significant reduction of diastolic blood pressure in the test-food group was confirmed 12 weeks after treatment compared with the control group (p<0.05). Conclusions: These results suggest that the lactic acid bacteria beverage containing C-COP is useful for reducing blood pressure of a person with high-normal blood pressure.