Metformin in Obese Children with Abnormal Glucose and Insulin Status

INTERVENTION: Previous interventions: 1. Metformin (500mg) 2. Placebo Current interventions as of 15/12/2008: 1. Metformin 1g mane, 500mg nocte 2. Placebo CONDITION: Nutritional, Metabolic, Endocrine: Obesity ; Nutritional, Metabolic, Endocrine ; Obesity PRIMARY OUTCOME: Reduction in BMI SDS. SECONDARY OUTCOME: Added 16 December 2008: fasting and 2 hr insulin and glucose levels on OGTT, measures of insulin resistance, fasting lipids, CRP, adiponectin, leptin, resistin, blood pressure. INCLUSION CRITERIA: Prior to 16 December 2008: 80 patients aged between 9‐18 years old As of 16 December 2008: 1. Pubertal and post‐pubertal children : Fasting insulin > 26 mIU/l 2. Pre‐pubertal children : Fasting insulin > 15 mIU/l 3. 120 minute insulin > 89 mIu/l AND/OR Impaired glucose tolerance ie: OGTT 2hr plasma glucose value > or = 7.8 to <11.1 (+/‐ impaired fasting glucose > or = 6.1 to < 7)