Impact of BPC-157 on Recovery Following Rotator Cuff Repair Surgery

This study is a randomized, double‐blind, placebo‐controlled pilot trial investigatingthe effects of BPC‐157 on tendon healing and functional recovery following arthroscopicrotator cuff repair (aRCR). BPC‐157 is a synthetic peptide that has demonstratedpromising regenerative and anti‐inflammatory effects in preclinical animal models ofmusculoskeletal injury, but it has not yet been studied in formal human clinical trials.Twenty patients undergoing aRCR will be enrolled and randomly assigned to receive eitherBPC‐157 or a saline placebo. Participants will self‐administer subcutaneous injectionsdaily for 90 days following surgery. All other aspects of care will follow the standardpostoperative rehabilitation protocol.The study will assess tendon healing using postoperative MRI, patient‐reported outcomemeasures (PROMs), range of motion (ROM), and muscle strength via handheld dynamometry.Blood samples will also be collected to evaluate biomarkers associated with collagenturnover and inflammation.The goal of this pilot study is to evaluate the safety, feasibility, and preliminaryefficacy of BPC‐157 in promoting tendon healing and improving functional outcomes afterrotator cuff repair. Results will inform the design of a future larger‐scale clinicaltrial.