Effects of Electroacupuncture on B-Lymphocyte Immunosuppression in Postoperative Delirium and Its Regulation Mechanism of Autonomic Nerve Activity

INTERVENTION: EA group:Electroacupuncture stimulation at bilateral Neiguan (PC6) and Shenmen (HT7) points;Sham EA group:Sham acupuncture stimulation at sham PC6 and sham HT7 points; CONDITION: Postoperative Delirium PRIMARY OUTCOME: Incidence of postoperative delirium (POD); SECONDARY OUTCOME: Severity of postoperative delirium;Heart rate variability parameters;Peripheral blood biomarkers of different autonomic nervous system activities;Functional changes in peripheral blood B lymphocytes;Levels and apoptosis of peripheral blood B lymphocytes and their subsets; INCLUSION CRITERIA: 1. Age range: 65 ‐ 90 years old; 2. ASA grade I ‐ III; 3. Scheduled for non‐cranial 3‐4 grade surgeries; 4. Mini‐Mental State Examination (MMSE) score < 24 (combined with cognitive impairment, refer to CIRCULATION. 2024; 150(4): 272‐282.); 5. The patient or their family can provide written informed consent.