Plexus brachialis block and circulation. Comparing effects on skin microcirculation and macro circulation of lidocain brachial plexus block with versus without epinephrine.

INTERVENTION: Trade Name: Lidocain Pharmaceutical Form: Injection Trade Name: Adrenalin Pharmaceutical Form: Injection CONDITION: human microcirculation and haemodynamic changes (macrosirculation) in healthy volunteers. Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] ‐ Anesthesia and Analgesia [E03] PRIMARY OUTCOME: Main Objective: To establish the effect of epinephrine when added to lidocain in brachial plexus block on human skin microcirculation and haemodynamic changes (macrosirculation) in men. Primary end point(s): Comparing effects on microcirculation and macrocirculation of lidocain brachial plexus block with epinephrine versus without epinephrine. Secondary Objective: Not applicable Timepoint(s) of evaluation of this end point: 40 minutes SECONDARY OUTCOME: Secondary end point(s): Comparation of different methods for circulation monitoring (laser doppler, temperature, capillary microscopy and spectroscopy, beat‐to‐beat Finometer measurements). Timepoint(s) of evaluation of this end point: 40 min INCLUSION CRITERIA: We will include 12 healthy volunteers in each study, age 18 – 60, ASA 1‐2. Non‐smokers. No intake of coffee, black tea or garlic last 12 hours. No regular medication. BMI 18‐35. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range 12 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range 0