Reducing pain intensity in neonates by multisensory stimulation

INTERVENTION: Randomisation with a block randomisation method to 3 interventions: Multisensory stimulation (modification of sensorial saturation/SS): 1. SS analgesia methods of modified breast milk (test group): ‐ Prepare 1 cc syringe and 1 cc of breast milk ‐ Start talking to the baby 30 seconds before blood sample collection ‐ Gently massage baby’s face ‐ Bring the breast milk closer to baby’s nose ‐ Give breast milk until the baby sucks rhythmically ‐ Perform blood sample collection while doing those maneuvers ‐ Continue gentle massage and speak to the baby until the end of the procedure ‐ Measure pain intensity using PIPP‐R instrument 2. Standard SS analgesia method (reference group): ‐ Prepare a vial of sucrose 24 % ‐ Start talking to the baby 30 seconds before blood sample collection ‐ Gently massage the baby’s face ‐ Give sucrose 24 % until he/she sucks rhythmically ‐ Perform blood sample collection while doing those maneuvers ‐ Continue gentle massage and talking to the baby until the end of the procedure ‐ Measure pain intensity using PIPP‐R instrument 3. Sucrose 24% analgesia method (control group): ‐ Prepare the baby for blood sample collection ‐ Prepare a vial of sucrose 24% ‐ Give sucrose 24 % until he/she sucks rhythmically ‐ Perform blood sample collection while doing those maneuvers ‐ Measure pain intensity using PIPP‐R instrument CONDITION: 2 to 28 days old babies admitted to neonatal ward who underwent peripheral blood sampling procedure ; Neonatal Diseases PRIMARY OUTCOME: Pain intensity measured using PIPP‐R (Premature Infant Pain Profile‐Revised) at a single timepoint SECONDARY OUTCOME: There are no secondary outcome measures INCLUSION CRITERIA: 1. Baby undergoing peripheral blood sampling procedure 2. Minimum APGAR Score of 9 at 5 minutes 3. Gestational age > 32 weeks 4. Postnatal age of 48 hours 5. Sucking and swallowing reflex (+) 6. On treatment for less than 7 days 7. Received breast milk from mother