Study comparing localised hand psoralen immersion combined with ultraviolet A (PUVA) with localised hand narrowband ultraviolet B (UVB) for the treatment of hand eczema

INTERVENTION: 76 participants will be randomised to two groups: Group 1 will receive narrow band UVB phototherapy to the hands. Hands will be exposed to UVB light. Group 2 will receive PUVA phototherapy to the hands. Hands will be soaked in a diluted solution of Psoralen and the exposed to UVA light. CONDITION: Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology ; Skin and Connective Tissue Diseases ; Atopic dermatitis PRIMARY OUTCOME: The proportion of patients responding (clear or almost clear PGA score) Timepoint(s): 12 weeks SECONDARY OUTCOME: 1. The percentage improvement in the Modified Total Lesion Symptom Score (mTLSS); 2. Dermatology Life Quality Index (DLQI)); 3. Health economic evaluation INCLUSION CRITERIA: 1. Patient has provided written informed consent for participation in the study prior to any study specific procedures 2. Palmar eczema not responding to topical treatments 3. Over 18 years of age 4. No topical treatments (except emollients for 48 hours) 5. No systemic treatments for eczema treatment for 3 months 6. Absence of clinical evidence of bacterial, fungal or viral infection 7. Not pregnant 8. Target Gender: Male & Female