The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)

Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2023
The goals of this project are to determine the effectiveness of acute (2 hours after a single dose) and chronic (after 6 weeks of once-a-day dosing) KNO3 treatment (10mmol) vs. placebo on quadriceps muscle power and on aerobic exercise performance (V̇O2peak) in patients with HFrEF (left ventricular ejection fraction \<45%). The investigators hypothesize that both acute and chronic dosing of 10mmol of KNO3 will improve exercise performance in HFrEF. To test this hypothesis, the investors will perform a randomized, double-blind, placebo-controlled, parallel-arm design study.
Epistemonikos ID: e9770c882905e1164b3cd735920ef492ecd6de5d
First added on: May 13, 2024