Transcutaneous Trigeminal Nerve Stimulation for Cognitive Dysfunction Following Traumatic Brain Injury

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Conventional Treatment Group:Routine rehabilitation for cognitive function and sham transcutaneous trigeminal nerve stimulation;Transcutaneous Trigeminal Nerve Stimulation group:Routine treatment for cognitive impairment (i.e., the standard care group protocol) and transcutaneous trigeminal nerve stimulation; CONDITION: Cognitive dysfunction following traumatic brain injury PRIMARY OUTCOME: Cognitive improvement index; SECONDARY OUTCOME: Modified Barthel Inde Xscore;Electroencephalography (EEG);Functional Near‐Infrared Spectroscopy (fNIRS);MMSE score;MoCA score;P300 event‐related potential amplitude and latency; INCLUSION CRITERIA: 1. Positive history of significant TBI; 2. Diagnosis of traumatic brain injury confirmed by cranial CT or MRI; 3. No pre‐existing cognitive impairment prior to this episode; 4. No previous exposure to structured cognitive rehabilitation or trigeminal nerve stimulation; 5. Age between 18 and 65 years; 6. Disease duration from onset to hospitalization at the study center exceeding 28 days; 7. Educational level of primary school or above; Mini‐Mental State Examination (MMSE) cutoff scores defined as <= 20 for primary school education and <=24 for middle school education or above; 8. Written informed consent obtained from the patient or their authorized legal representative for cognitive rehabilitation and TNS therapy.
Epistemonikos ID: e904ff92288e8bbb0016c854b5e1ce253448f271
First added on: Oct 08, 2026