Crucumin Effects on the Immune System in Osteoarthritis Patients

The purpose of this study was to evaluate the effect of the active ingredient of crucumin on the reduction of symptoms of osteoarthritis. Of the 30 patients participating in this study, a blood sample will be taken at the beginning of the study, and then after three months of taking the crucumin. To evaluate the response to treatment, after each person sampling, we will analyze cell count for Th‐1, Th‐17, TReg and Ly.B by flowcytomtry method. Also we will measure cytokines level of IL‐17, CXCL8, CX3CL1 and April by ELISA method. Finally we evaluate the gene expression of MicroRNA‐720, MicroRNA‐155, MicroRNA‐146a and MicroRNA‐16 by Real Time PCR technique.