Evaluation of the effect of curcumin-piperine in the treatment of rheumatoid arthritis

INTERVENTION: Intervention 1: Intervention group: Take one capsule containing curcumin piperine daily (containing 500 mg curcumin extract and 5 mg piperine) for 12 weeks. They will also receive diet and exercise advice.Dietary recommendations mainly include emphasizing the consumption of foods containing antioxidants in order to reduce inflammation and prevent the increase of inflammation, such as the cabbage and berry family. It is also recommended that people do a little physical activity that does not increase the problems caused by rheumatoid arthritis and help improve the condition. Intervention 2: Control group: They will receive one placebo capsule (500 mg of maltodextrin) daily with diet and exercise recommendations. Dietary recommendations mainly include emphasizing the consumption of foods containing antioxidants in order to reduce inflammation and prevent the increase of inflammation, such as the cabbage and berry family. It is also recommended that people do a little physical activity that does not increase the problems caused by rheumatoid arthritis and help improve the condition. CONDITION: Rheumatoid Arthritis. ; Rheumatoid arthritis with rheumatoid factor PRIMARY OUTCOME: C‐reactive protein (CRP). Timepoint: Beginning and end of the study. Method of measurement: Colorimetric analysis method and by autoanalyzer. Cholesterol. Timepoint: Beginning and end of the study. Method of measurement: Colorimetric analysis method and by autoanalyzer. Clinical signs. Timepoint: Beginning and end of the study. Method of measurement: Diagnosis by a specialist. DAS. Timepoint: Beginning and end of the study. Method of measurement: DASS questionnaire. ESR. Timepoint: Beginning and end of the study. Method of measurement: Enzymatic method. Fasting blood sugar. Timepoint: Beginning and end of the study. Method of measurement: Colorimetric analysis method and by autoanalyzer. High‐density lipoprotein (HDL). Timepoint: Beginning and end of the study. Method of measurement: Colorimetric analysis method and by autoanalyzer. Low density lipoprotein (LDL). Timepoint: Beginning and end of the study. Method of measurement: Colorimetric analysis method and by autoanalyzer. Triglyceride. Timepoint: Beginning and end of the study. Method of measurement: Colorimetric analysis method and by autoanalyzer. INCLUSION CRITERIA: Willingness to participate in the study Age: 20‐65 years Complete informed consent Rheumatoid arthritis according to the rheumatologist according to the criteria of the American College of Rheumatology 2010 Disease activity score higher than 1/5 and total soft joint count (TJC) and swollen joint count (SJC) higher than 8