The BREATH study

INTERVENTION: ‐ Partial neuromuscular block with rocuronium ‐ Hypoxic and hypercapnic ventilatoy respons ‐ Antagonizing neuromuscular block with either neostigmine or sugammadex or placebo CONDITION: Neuromuscular blockade, Carotid bodies ; ; PRIMARY OUTCOME: ‐ The effect of partial neuromuscular blockade (NMB; TOF ratio 0.8 and 0.6) induced by low‐dose rocuronium on the ventilatory response to isocapnic hypoxia and the effect over time (from TOF 0.6 to TOF 1.0) of the reversal by sugammadex, neostigmine or placebo in healthy volunteers SECONDARY OUTCOME: To assess the effect of partial NMB (TOF ratio 0.6) induced by low‐dose rocuronium on the ventilatory response to hypercapnia and effect over time (from TOF 0.6 to TOF 1.0) of the reversal by sugammadex, neostigmine or placebo in healthy volunteers. INCLUSION CRITERIA: Healthy male volunteers aged 18 and older with a body mass index < 30 kg/m2.