Atovaquone-resistant Plasmodium falciparum in Central Africa

INTERVENTION: treatment with artesunate‐amodiaquine (recommended by the national drug policy) treatment with atovaquone‐proguanil treatment with artesunate‐atovaquone‐proguanil CONDITION: target disease ‐ malaria PRIMARY OUTCOME: adequate clinical and parasitological response versus treatment failure on day 28, as defined by the World Health Organization SECONDARY OUTCOME: parasite and fever clearance times INCLUSION CRITERIA: fever at the time of consultation, presence of Plasmodium falciparum with a parasite density more than 2,000 asexual parasites per microlitre of blood