Sequential Optimization of Dose and Schedule of PfSPZ Vaccine

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2016
MAVACHE is a sequential dose and schedule optimization trial of intravenous immunization with PfSPZ Vaccine in 18 to 54 malaria-naïve, healthy adult volunteers receiving 9x10\^5, 1.35x10\^6, or 2.7x10\^6 PfSPZ per dose and a total dose between 2.7x10\^6 and 8.1x10\^6 PfSPZ followed by CHMI with 3,200 fully infectious PfSPZ (PfSPZ Challenge). PfSPZ Challenge (7G8) to assess vaccine efficacy, safety, tolerability and infectivity of ascending PfSPZ doses will be assessed in healthy, malaria-naïve volunteers.
Epistemonikos ID: e7760b60a2c58c1502cd91e177cdffdbada22f16
First added on: May 12, 2024