Multi-centric randomized open-label comparative study for influence of bisphosphonate on fracture healing in patients with spinal compression fractures or femoral neck fractures

INTERVENTION: Sodium risedronate hydrate was given from 1 week after injury or surgery in group A. Sodium risedronate hydrate was given from 3 months after injury or surgery in group B. CONDITION: Osteoporotic spinal compression fractures and femoral neck fractures PRIMARY OUTCOME: Fracture healing is assessed with X ray film and computed tomograhy, and QOL is assessed with questionnaires. SECONDARY OUTCOME: Bone mineral density, visual analogue scale and bone markers are measured. INCLUSION CRITERIA: Inclusion criteria are primary osteoporosis patients with the age of 65 to 90 years old, osteoporotic spinal compression fractures, and osteoporotic femoral neck fractures.