A randomized trial to compare efficacy and safety of cyclosporin-prednisone versus mycophenolate mofetil-prednisone, 3 months after renal transplantation.

INTERVENTION: mycophenolate mofetil 2g per day and prednisone 0.15 mg/kg, per day from month 3 to 12 post graft. Both drugs: oral capsules CONDITION: Renal transplantation PRIMARY OUTCOME: Incidence of biopsy‐proven acute allograft rejection during the first post‐transplant year SECONDARY OUTCOME: Chronic Allograft Dysfunction Index (CADI) graft and patient survival (the date of the graft failure was defined as the day when dialysis was restarted or patient death) Serum creatinine INCLUSION CRITERIA: 1) First renal transplantation from a deceased donor under a triple drug regimen (cyclosporine + mycophenolate mofetil + prednisone) 2) No acute rejection episode during the first 3 months post graft (time of randomisation) 3) Patients who gave their informed consent and are able to understand the scope of the study