A prospective, multicenter, double-blind, randomized controlled clinical study was conducted to evaluate the efficacy and safety of cross-linked sodium hyaluronate gel for injection in correcting moderate to severe nasolabial wrinkles in adult

INTERVENTION: Test (left) ‐ control (right) group:Sodium Hyaluronate Gel for Injection;Test (right) ‐ control (left) group:Sodium Hyaluronate Gel for Injection; CONDITION: Nasolabial groove wrinkle PRIMARY OUTCOME: Wrinkle rating; SECONDARY OUTCOME: Overall beauty effect score;Pain score; INCLUSION CRITERIA: Subjects who meet all the following conditions can be enrolled in this study: (1) Voluntary participation and signing of written informed consent; (2) The age is 18 65 years old, regardless of gender; (3) The severity score (WSRS) of bilateral nasolabial furrow wrinkles assessed by the blind evaluation researcher is moderate or severe (grade 3 or 4), and the bilateral scores need not be consistent, and the treatment researcher approves the score; (4) During the study period, he voluntarily gave up any other facial surgery under the eyes (including nose); (5) Willing to complete all visits according to the requirements of the test plan.