[Study on clinical intervention of jiawei shengdan louxie sini fang on coronary heart disease with depression].

OBJECTIVE: To study the differentiation of symptoms and signs of major syndrome factors of traditional Chinese medicine and the efficacy of Jiawei Shengdan Louxie Sini Fang combined with methods for nourishing qi and yin, promoting blood circulation, nourishing heart and kidney, soothing and nourishing liver and reducing phlegm. METHOD: In the randomized controlled clinical trial, patients of coronary heart disease with stable angina and depression are selected and divided into the traditional Chinese medicine intervention group and the western medicine control group. Maintaining the basic treatment with western medicines for coronary heart disease, the Chinese traditional medicine group was administered with Jiawei Shengdan Louxie Sini Fang, while the western medicine control group fluoxetine. RESULT: Compared with the control group, the traditional Chinese medicine group was better in angina curative effect, syndrome curative effect and HAMA rating scale. In the comparison for sign and symptom score, the test group was better than the control group in short of breath, lack of power, self-sweat, night sweats, insomnia, frequent micturition in night, constipation, abdominal distension, frequent deep sigh, pharynx obstruction and dark color of lips. CONCLUSION: Intervention with traditional Chinese medicine can ameliorate angina and other symptoms of whole body. It can also improve anxiety scores of patients in order to reduce the impact of depression and anxiety on coronary heart disease.