Effect of Jingujian granule on 129 primary osteoporosis cases

OBJECTIVE : To observe the effect of Jingujian Granule (Granule for strengthening the bones) No.1,2,and 3 on primary osteoporosis in the TCM syndromes of liver-kidney deficiency,both spleen and kidney deficiency,and spleen and kidney deficiency accompanied with blood stasis,and the influence on the bone metabolism indices. METHODS : Totally 210 primary osteoporosis cases were differentiated according to the TCM differentiation and administered Jingujian Granule No.1,2,3 or Caltrate D accordingly.The observation was carried out for 3 months on the improvement of clinical symptoms,changes in bone mineral density and bone metabolism indices,and safety indices. RESULTS : The total effective rate of Jingujian Granule No.1,2,and 3 was 89.92%,while that of Caltrate D was 33.3% (P0.01).The Chinese herbal medicine was better than Caltrat D in improving the symptoms (P0.05).Jingujian Granule had the functions to decrease acid phosphatase and osteoprotegerin,and increase alkaline phosphatase,estradiol,osteocalcin,and calcitonin,being more effective than Caltrate D (P0.05 or P0.01). CONCLUSION : Jingujian Granule is better in effect than Caltrate D for primary osteoporosis.