Trial in HPV Prevention for the U.S. Vietnamese Community

The purpose of the HERO study is to leverage the Multiphase Optimization Strategy (MOST)framework to conduct a pilot trial testing four different intervention components (expertvideo, self‐persuasion, narrative storytelling, and motivational interviewing) targetingHPV vaccination among U.S. Vietnamese.PRIMARY AIM To assess the feasibility and acceptability of each of the four digital HEROintervention components in a pilot optimization trial using the MOST framework. Using ahighly efficient design, the study team will randomize 96 Vietnamese parents ofunvaccinated adolescents to receive 0 to 4 HERO components. The study team will establishthe feasibility (reach, retention, adherence) and acceptability (usability, satisfaction,usefulness, cultural relevance) of each component (expert video, self‐persuasion,narrative storytelling, and motivational interviewing).SECONDARY AIM To investigate effects of each component on HPV vaccination outcomes andpsychosocial mediators. The study team will examine the effects on HPV vaccination(initiation and intention) and psychosocial mediators.Research participants will be identified and recruited through online recruitment,community organizations, social media, research team social networks and personalcontacts, and in‐person events targeting U.S. Vietnamese parents of adolescents.Interested potential participants will answer an online screener for eligibility. Whenappropriate, potential participants can also be screened via a brief Zoom, telephone, orin‐person interview. Once a participant is determined to be eligible for studyparticipation, the study team will communicate via telephone or send a follow up email tothem to invite them to participate in the research. Participants will provide eConsentvia a form hosted on REDCap, including accepting that the interviews will be audio and/orvideo recorded. After consent is received, all additional study procedures will behandled by the study team.Assessments. Participants will also fill out a short survey that capturessociodemographic information and vaccine beliefs and attitudes. This short survey cannotbe completed until after participants have consented to participate. Participants willcomplete follow‐up assessments at 1, 3, and 6 months post‐baseline, including a surveyand interview at Month 1 and surveys at Months 3 and 6.Randomization and Study Orientation. Following the completion of the baseline assessment,participants will be randomized using computer‐generated randomly permuted blocks,stratified by the sex of the adolescent (to acknowledge historical differences in HPVuptake among male and female adolescents). All participants will receive the constantcomponent through the study website. Depending on the intervention condition,participants will receive 0 to 4 intervention components and complete them within 4 weeksfrom the baseline assessment.Intervention ComponentsConstant component: Each participant will receive the constant component through thestudy website, which includes a vaccine information statement from the CDC with detailson HPV vaccine benefits, potential side effects, and recommended vaccination schedule, aswell as online information on access and locations for HPV vaccine (e.g., list ofVaccines for Children providers where Medicaid, uninsured, or underinsured adolescentscan be vaccinated for free).Expert video: Participants will watch a video featuring Vietnamese healthcare providers.In the video, the providers will endorse vaccine safety and efficacy, dispel commonmisconceptions or concerns, and use verbal persuasion techniques to recommend HPVvaccination.Self‐persuasion: Participants will complete an interactive web‐based task where theyaudio record reasons, summarized in their own words, for getting their adolescent the HPVvaccine.Narrative storytelling: Participants will watch a video featuring U.S. Vietnameseparents. In the video, featured parents will describe stories of their experienceslearning about the HPV vaccine as well as motivations to initiate and complete thevaccine series on‐time for their adolescents.Motivational interviewing: Participants will receive 2 calls (phone or Zoom) from atrained U.S. Vietnamese health educator. The health educator will use motivationinterviewing (e.g., open‐ended questions, acknowledging feelings, affirmations,reflective listening) to increase opportunities for and commitment to HPV vaccinationwhile decreasing barriers (e.g., safety or access concerns).Participants will be followed for a maximum of 6 months from the baseline assessment andwill complete up to 3 additional assessments (1‐month, 3‐month, and 4‐monthpost‐randomization).