Validation study to explore potential outcome parameters for a study with anti-IL-13 in allergic syndrome/asthma

INTERVENTION: Subjects underwent a nasal allergen challenge with a relevant allergen. CONDITION: Atopic rhinitis ; Respiratory ; Vasomotor and allergic rhinitis PRIMARY OUTCOME: Primary study objectives:; 1. To test the reproducibility, in atopic subjects with a clinically stable allergic rhinitis of: ; 1.1. SPT ; 1.2. Relevant markers of allergic rhinitis and atopy in peripheral blood; 2. To validate the following assays for measuring relevant biomarkers in atopic subjects with a clinically stable allergic rhinitis:; 2.1. Exhaled nasal air; 2.2. Peripheral blood; 2.3. Nasal lavage; 2.4. Nasal brush SECONDARY OUTCOME: To identify an appropriate study population for intervention studies with anti‐allergic agents such as anti‐IL13. INCLUSION CRITERIA: 1. Male or female subjects 2. 18‐50 years of age with atopic rhinitis